Dacremont G, De Baets M, Kaufman J M, Elewaut A, Vermeulen A
Biochim Biophys Acta. 1984 Mar 14;770(2):142-7. doi: 10.1016/0005-2736(84)90123-8.
Gangliosides inhibit basal, thyrotropin-induced and fluoride-induced adenylate cyclase activity of human thyroid membranes in physiological conditions. In contrast neutral glycolipids, phospholipids and neuraminic acid containing oligosaccharides show no effect. The efficacy of inhibition is more dependent upon the position of the sialic acid residues than upon their absolute number. In general gangliosides with disialyl groups are more inhibitory than those with single sialyl moieties. The inhibitory effects of the individual gangliosides on the two modes of stimulation are parallel. This parallelism suggests that the inhibitory effect is located at the postreceptor level and that the gangliosides interact directly with the adenylate cyclase system. A possible role of thyroid membrane gangliosides as suppressive cofactors of adenylate cyclase is discussed in relation to recent findings of stimulating anti-ganglioside antibodies in Graves' disease.
在生理条件下，神经节苷脂可抑制人甲状腺膜的基础、促甲状腺激素诱导和氟诱导的腺苷酸环化酶活性。相比之下，中性糖脂、磷脂和含神经氨酸的寡糖则无此作用。抑制效果更多地取决于唾液酸残基的位置，而非其绝对数量。一般来说，含双唾液酸基团的神经节苷脂比含单个唾液酸部分的神经节苷脂抑制作用更强。各神经节苷脂对两种刺激模式的抑制作用是平行的。这种平行性表明抑制作用位于受体后水平，且神经节苷脂直接与腺苷酸环化酶系统相互作用。结合近期在格雷夫斯病中发现的刺激抗神经节苷脂抗体，讨论了甲状腺膜神经节苷脂作为腺苷酸环化酶抑制性辅助因子的可能作用。
