系统性红斑狼疮（SLE）患者中“补体”受体介导的吞噬作用存在内在细胞缺陷的证据。
Evidence for intrinsic cellular defects of 'complement' receptor-mediated phagocytosis in patients with systemic lupus erythematosus (SLE).
作者信息
Hurst N P, Nuki G, Wallington T
出版信息
Clin Exp Immunol. 1984 Feb;55(2):303-12.
Abstract
Fc and 'complement'-mediated phagocytosis of pre-opsonized yeast has been studied in monocytes from 18 patients with SLE. Monocytes from nine of 18 patients had depressed complement-mediated phagocytosis (P = 0.0001, Fishers exact test) but only three of 18 had depressed Fc-mediated phagocytosis (NS, Fishers exact test). Although reduced complement-mediated phagocytosis was correlated with increased frequency of disease manifestations (P less than 0.003, rank correlation) there was no correlation with serum DNA or C1q binding activity, C3 or C4 levels. Serum from SLE patients with depressed phagocytosis did not inhibit phagocytosis by normal monocytes. The data suggests the presence of intrinsic abnormalities of monocyte receptor function in SLE and the nature of the 'complement' receptors involved is discussed.
摘要
对18例系统性红斑狼疮（SLE）患者单核细胞中预致敏酵母的Fc介导和“补体”介导的吞噬作用进行了研究。18例患者中有9例的单核细胞补体介导的吞噬作用降低（P = 0.0001，Fisher精确检验），但18例中只有3例的Fc介导的吞噬作用降低（无显著性差异，Fisher精确检验）。虽然补体介导的吞噬作用降低与疾病表现频率增加相关（P < 0.003，等级相关），但与血清DNA或C1q结合活性、C3或C4水平无关。吞噬作用降低的SLE患者血清不会抑制正常单核细胞的吞噬作用。数据表明SLE中存在单核细胞受体功能的内在异常，并讨论了所涉及的“补体”受体的性质。
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