三种免疫复合物检测方法在系统性红斑狼疮治疗中的价值：评估免疫复合物水平、大小及免疫化学特性与疾病活动和表现的关系
The value of three immune complex assays in the management of systemic lupus erythematosus: an assessment of immune complex levels, size and immunochemical properties in relation to disease activity and manifestations.
作者信息
Cairns S A, London A, Mallick N P
出版信息
Clin Exp Immunol. 1980 May;40(2):273-82.
Abstract
Sixteen patients with systemic lupus erythematosus, fourteen with renal involvement have been studied over a 30-month period. Circulating immune complex levels have been assayed by three techniques. The results of tests on 141 sequential sera suggest that the three assays detected overlapping populations of the range of complexes present. Immune complex levels are shown to be good markers of disease activity and certain immunochemical properties of the complexes emerged as better markers than others. Immune complex size is a more important determinant of disease manifestation than are overall immune complex levels. High doses of intravenous methyl prednisolone, which did not reduce overall complex levels, reduced levels of those complexes (molecular weight 600,000-900,000 Daltons) associated with renal involvement.
摘要
在30个月的时间里，对16例系统性红斑狼疮患者进行了研究，其中14例有肾脏受累。采用三种技术检测了循环免疫复合物水平。对141份连续血清的检测结果表明，这三种检测方法检测到的复合物范围有重叠。免疫复合物水平被证明是疾病活动的良好标志物，并且复合物的某些免疫化学特性比其他特性更能作为良好的标志物。免疫复合物大小比总体免疫复合物水平更能决定疾病表现。高剂量静脉注射甲基泼尼松龙虽未降低总体复合物水平，但降低了与肾脏受累相关的那些复合物（分子量600,000 - 900,000道尔顿）的水平。
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本文引用的文献
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Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase C1q.使用固相C1q检测已知免疫球蛋白类别的免疫复合物的常规检测方法。
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