Saatok T, Dahlberg E, Bylund P, Eriksson E, Gustafsson J A
Clin Orthop Relat Res. 1984 Mar(183):197-207.
To investigate the possible influence of steroid hormones on the back muscles of scoliotic patients, steroid receptors, protein, and DNA were analyzed in muscle from 20 patients of both sexes, at different ages, and with different clinical diagnoses. Androgen and glucocorticoid receptors, but no estrogen receptors, were found. The androgen and glucocorticoid receptors had binding characteristics similar to those of corresponding receptors in other mammalian skeletal muscle, including that of humans. Whereas the concentration of androgen receptors was similar on both sides of the curve, the concentration of glucocorticoid receptors per gram of tissue (wet weight) was higher on the convex side. There were no side differences in steroid receptor content when measured per milligram of protein or per milligram of DNA. The concentrations of protein and DNA were higher on the convex than on the concave side and resulted in lower protein/DNA ratios on the former side indicating smaller "cell units" in muscle on the convex side. These data suggest that the side differences in scoliotic erector spinae muscle for these growth parameters can be secondary to the reported different distribution of fiber types on both sides, but they can also be due to a difference in growth of the muscle cells on the two sides.
为研究类固醇激素对脊柱侧弯患者背部肌肉可能产生的影响，对20名不同性别、年龄及临床诊断的患者的肌肉组织进行了类固醇受体、蛋白质和DNA分析。结果发现了雄激素和糖皮质激素受体，但未发现雌激素受体。雄激素和糖皮质激素受体的结合特性与其他哺乳动物（包括人类）骨骼肌中的相应受体相似。虽然曲线两侧雄激素受体的浓度相似，但每克组织（湿重）中糖皮质激素受体的浓度在凸侧更高。以每毫克蛋白质或每毫克DNA计算时，类固醇受体含量没有侧别差异。蛋白质和DNA的浓度在凸侧高于凹侧，导致凸侧的蛋白质/DNA比值较低，表明凸侧肌肉中的“细胞单位”较小。这些数据表明，脊柱侧弯竖脊肌在这些生长参数上的侧别差异可能继发于两侧已报道的不同纤维类型分布，但也可能是由于两侧肌肉细胞生长的差异。
