Shippy C R, Appel P L, Shoemaker W C
Crit Care Med. 1984 Feb;12(2):107-12. doi: 10.1097/00003246-198402000-00005.
Blood volumes measured by indicator dilution method in over 1500 instances of critically ill patients of various etiologies and at various times throughout their critical illness were compared with the values of concomitantly measured mean arterial pressure (MAP), CVP, pulmonary arterial wedge pressure (WP), Hct, and cardiac output. During resuscitation from hypovolemic shock, the patients' blood volumes and the monitored variables were significantly altered. However, there were poor correlations between the extent of blood volume changes and these variables during resuscitation as well as throughout the critical illness, irrespective of the etiologic type or stage of shock. With administration of a fluid load, blood volume and values of the commonly monitored variables improved appropriately, but the correlation coefficients, in general, were not good. The data suggest that the commonly monitored variables, in and of themselves, do not reflect adequately the blood volume status in critically ill patients.
通过指示剂稀释法对1500多例不同病因的危重症患者在其危重症期间的不同时间测量的血容量，与同时测量的平均动脉压（MAP）、中心静脉压（CVP）、肺动脉楔压（WP）、血细胞比容（Hct）和心输出量的值进行了比较。在低血容量性休克复苏期间，患者的血容量和监测变量发生了显著变化。然而，在复苏期间以及整个危重症期间，无论休克的病因类型或阶段如何，血容量变化程度与这些变量之间的相关性都很差。给予液体负荷后，血容量和常用监测变量的值适当改善，但总体而言，相关系数并不理想。数据表明，常用监测变量本身并不能充分反映危重症患者的血容量状态。
