长期使用硝普钠时的维生素B12水平。

Vitamin B12 levels in the prolonged use of sodium nitroprusside.

作者信息

Lipman J, Hesdorffer C, Fernandes Costa F, Roos C P, Eidelman J, Plit M

出版信息

Crit Care Med. 1984 Mar;12(3):161-3. doi: 10.1097/00003246-198403000-00002.

DOI:10.1097/00003246-198403000-00002

Abstract

Long-term (greater than 48 h) sodium nitroprusside (SNP) infusion significantly reduced cobalamin (vitamin B12) levels in 23 patients treated in a CCU after myocardial infarction. There was no evidence of vitamin B12 deficiency or SNP toxicity. Low vitamin B12 levels should not limit the use of SNP, because prolonged infusion of SNP at maximum doses of 2.5 micrograms/kg X min did not adversely affect hemodynamic stability.

摘要

在冠心病监护病房（CCU）接受治疗的23例心肌梗死患者中，长期（超过48小时）输注硝普钠（SNP）可显著降低钴胺素（维生素B12）水平。没有证据表明存在维生素B12缺乏或SNP毒性。低维生素B12水平不应限制SNP的使用，因为以最大剂量2.5微克/千克×分钟长期输注SNP不会对血流动力学稳定性产生不利影响。