Johnson B E, Suratt P M, Gal T J, Wilhoit S C
Chest. 1984 Mar;85(3):325-8. doi: 10.1378/chest.85.3.325.
We compared the effects of inhaled glycopyrrolate (G), 1.3 mg, and atropine (A), 2.6 mg, and placebo on FEV1 and specific conductance (sGaw) before and after exercise in six men with exercise-induced asthma. Subjects exercised with cold air (-2 degrees C) 30 and 120 minutes after each aerosol treatment. Spirometry was performed and sGaw determined before aerosol treatment (baseline) and before and after exercise. Decreased airway tone was noted before exercising with A and G but not with placebo. The decreases in FEV1 and sGaw resulting from exercise were not significantly different among the three treatment groups at either exercise session. Postexercise FEV1 and sGaw were significantly higher after A and G compared to P. Dry mouth, flushing, and resting tachycardia were prominent with group A. Symptoms in G did not differ from those in P. This study suggests that A and G do not prevent bronchoconstriction induced by exercise and cold air but improve postexercise pulmonary function by achieving preexercise bronchodilation. Systemic side effects were minimal with G compared to A.
我们比较了吸入1.3毫克格隆溴铵（G）、2.6毫克阿托品（A）和安慰剂对6名运动诱发性哮喘男性患者运动前后第一秒用力呼气量（FEV1）和比气道传导率（sGaw）的影响。在每次气雾剂治疗后30分钟和120分钟，受试者在冷空气（-2摄氏度）中进行运动。在气雾剂治疗前（基线）以及运动前后进行肺量测定并测定sGaw。在使用A和G进行运动前观察到气道张力降低，但使用安慰剂时未观察到。在两个运动时段，三个治疗组因运动导致的FEV1和sGaw降低均无显著差异。与安慰剂相比，使用A和G后运动后FEV1和sGaw显著更高。A组口干、面部潮红和静息性心动过速较为突出。G组的症状与安慰剂组无差异。本研究表明，A和G不能预防运动和冷空气诱发的支气管收缩，但通过实现运动前支气管扩张来改善运动后肺功能。与A相比，G的全身副作用最小。
