Pirovino M, Meier J, Meyer M, Waldmeier P, Schmid M
Dtsch Med Wochenschr. 1984 Mar 9;109(10):378-81. doi: 10.1055/s-2008-1069199.
The neuroleptic malignant syndrome is clinically characterised by the presence of severe muscular rigidity, altered consciousness, hyperthermia and by signs of autonomic dysfunction. A severe form of the syndrome lasting several weeks was observed in a 20-year-old, mentally retarded female patient while under fluphenazine treatment. Cerebrospinal fluid was examined for monoamine metabolites by high-performance liquid chromatography both during the acute and the convalescent phases of the disease. Since the disease carries a considerable mortality, early diagnosis and rapid withdrawal of all neuroleptic medication is of primary importance.
神经阻滞剂恶性综合征的临床特征为严重的肌肉强直、意识改变、高热以及自主神经功能障碍的体征。一名20岁的智力发育迟缓女性患者在接受氟奋乃静治疗期间出现了持续数周的严重综合征形式。在疾病的急性期和恢复期均通过高效液相色谱法检测脑脊液中的单胺代谢产物。由于该疾病具有相当高的死亡率，早期诊断并迅速停用所有神经阻滞剂药物至关重要。
