Fabre S, Gervais C, Manuel C, Vic Dupont V
Encephale. 1977;3(4):321-6.
Seven cases of malignant syndrom due to neuroleptic drugs are reported, three of them in patients receiving long-acting medication. The authors point out the seriousness of such accidents, two of seven cases leading to death. Clinical features consist mainly of hyperthermia which can be erroneously attributed to infectious disease. Muscular hypertonicity is often associated with hyperthermia. Tetanus was evoked for two patients. In the absence of satisfactory physiopathologic explanation, treatment is merely symptomatic, based on intensive care. So far, this type of accident has been little known; it was important to focus our attention on it.
报告了7例因抗精神病药物引起的恶性综合征，其中3例患者接受的是长效药物治疗。作者指出了此类事故的严重性，7例中有2例导致死亡。临床特征主要为体温过高，这可能被错误地归因于传染病。肌肉张力过高常与体温过高相关。有两名患者出现了破伤风症状。由于缺乏令人满意的生理病理学解释，治疗仅基于重症监护进行对症治疗。到目前为止，这类事故鲜为人知；因此有必要对此予以关注。
