[肺结节病患者血清羧肽酶N的变化]

[Changes in serum carboxypeptidase N in patients with lung sarcoidosis].

作者信息

Schweisfurth H, Heinrich J, Brugger E, Burghardt W

出版信息

Dtsch Med Wochenschr. 1984 Feb 3;109(5):166-9. doi: 10.1055/s-2008-1069159.

DOI:10.1055/s-2008-1069159

Abstract

Serum carboxypeptidases N (E.C.3.4.17.3) were determined spectrophotometrically in 39 patients with untreated pulmonary sarcoidosis (radiographic stages I-II). Carboxypeptidases N were, due to variable substrate affinity, subdivided into N1 (CN1) and N2 (CN2). The control group consisted of 52 healthy persons. In addition, haemodynamics, chemical pathology, and lung function tests were evaluated. Among controls both CN1 and CN2 were slightly increased in females when compared to males. Patients with pulmonary sarcoidosis had significantly higher CN1 and CN2 activities (P less than 0.005) than the control group. Neither among healthy probands nor among patients with sarcoidosis were there positive correlations between haemodynamics, chemical pathology and lung function data on the one hand and CN1 and CN2 on the other. However, a linear correlation between CN1 and CN2 could be established in both groups (P less than 0.001).

摘要

采用分光光度法测定了39例未经治疗的肺结节病患者（影像学分期为I-II期）血清羧肽酶N（E.C.3.4.17.3）。由于底物亲和力不同，羧肽酶N被细分为N1（CN1）和N2（CN2）。对照组由52名健康人组成。此外，还评估了血流动力学、化学病理学和肺功能测试。在对照组中，女性的CN1和CN2均略高于男性。肺结节病患者的CN1和CN2活性显著高于对照组（P<0.005）。无论是在健康受试者还是结节病患者中，血流动力学、化学病理学和肺功能数据与CN1和CN2之间均无正相关。然而，两组中CN1和CN2之间均可建立线性相关性（P<0.001）。