Sehrt I, Christ R
Z Erkr Atmungsorgane. 1979 Jun;153(3):383-91.
Serum angiotensin converting enzyme activity was measured in 60 blood donors and 100 patients with sarcoidosis histologically confirmed using a spectrophotometric assay with hippurylhistidylleucine as substrate. Sex related differences in the enzyme activity could not be observed. ACE was found to be markedly raised above the normal range (the mean of the control subjects plus 2 standard deviations) in 53 (58.2%) out of 91 untreated patients. The distribution of the enzyme activities was significantly different as compared to the control group. Nine patients with sarcoidosis receiving steroids had a mean level within the normal range. ACE level in stage II group tended to be more elevated compared to stage I, but this difference was not significant. Extrapulmonary sarcoidosis (with and without pulmonary involvement) appeared to be associated with especially high ACE activities. The distribution of the enzyme activities within the groups of untreated patients failed to reveal statistically significant differences. Therefore it was not possible to determine the clinical state of the disease and to discriminate between the stages (I and II) of sarcoidosis by the measurement of serum ACE level. However as the results suggest serum ACE assays can be a useful aid in diagnosis of sarcoidosis. Further investigations may demonstrate the value of this in vitro method for the clinical management of the disease including prognosis and therapeutic effects.
采用以马尿酰 - 组氨酰 - 亮氨酸为底物的分光光度法，对60名献血者和100名经组织学确诊的结节病患者测定了血清血管紧张素转换酶活性。未观察到酶活性的性别差异。在91名未经治疗的患者中，有53名（58.2%）的血管紧张素转换酶（ACE）水平明显高于正常范围（对照组均值加2个标准差）。与对照组相比，酶活性分布有显著差异。9名接受类固醇治疗的结节病患者的平均水平在正常范围内。与I期相比，II期组的ACE水平有升高趋势，但差异不显著。肺外结节病（无论有无肺部受累）似乎与特别高的ACE活性有关。未经治疗患者组内的酶活性分布未显示出统计学上的显著差异。因此，通过测定血清ACE水平无法确定疾病的临床状态，也无法区分结节病的分期（I期和II期）。然而，正如结果所示，血清ACE检测在结节病的诊断中可能是一种有用的辅助手段。进一步的研究可能会证明这种体外方法在疾病临床管理（包括预后和治疗效果）中的价值。
