脾肿大、吞噬作用增强和贫血是对疟疾的胸腺依赖性反应。
Splenomegaly, enhanced phagocytosis, and anemia are thymus-dependent responses to malaria.
作者信息
Roberts D W, Weidanz W P
出版信息
Infect Immun. 1978 Jun;20(3):728-31. doi: 10.1128/iai.20.3.728-731.1978.
Abstract
Immunologically competent mice and mice with defined immunological deficiencies were infected with Plasmodium yoelii. Splenomegaly, enhanced phagocytosis, and anemia were most marked in infected mice having intact thymic tissue. Whereas the spleens of infected nude mice increased minimally in size, the relative blood hemoglobin levels and the rates of carbon clearance in these mice were similar to those of noninfected, immunologically intact mice. Thymus-reconstituted nude mice and B-cell-deficient mice responded to infection in a manner similar to that of infected immunocompetent mice. These data demonstrate that the hallmarks of malaria, i.e., splenomegaly, enhanced phagocytosis, and anemia, are thymus-dependent responses to infection.
摘要
将具有免疫活性的小鼠和具有特定免疫缺陷的小鼠感染约氏疟原虫。脾肿大、吞噬作用增强和贫血在具有完整胸腺组织的感染小鼠中最为明显。而感染的裸鼠脾脏大小增加最小，这些小鼠的相对血血红蛋白水平和碳清除率与未感染、免疫功能正常的小鼠相似。胸腺重建的裸鼠和B细胞缺陷小鼠对感染的反应方式与感染的免疫活性小鼠相似。这些数据表明，疟疾的特征，即脾肿大、吞噬作用增强和贫血，是对感染的胸腺依赖性反应。
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