Rosenman J, Perrone T
Int J Radiat Oncol Biol Phys. 1984 Jan;10(1):63-7. doi: 10.1016/0360-3016(84)90413-9.
Although much research has been done to isolate factors that have good prognostic value for cure in breast cancer, comparatively little attention has been paid to the large variation in the metastasis-free interval (MFI) in those who are not cured. In this paper we studied 247 patients who were given curative treatment for breast cancer, all of whom developed metastatic disease. The MFI varied from 2 months to 22 years and was found to depend on nodal status, initial T-stage, and possibly, location of the tumor within the breast; it did not depend on age of the patient or histologic appearance of the tumor. In addition, the time from first relapse to death did not correlate with the MFI. With one exception (brain) the initial site of distant metastasis was the same in late relapsers as in early relapsers.
尽管已经开展了大量研究来分离出对乳腺癌治愈具有良好预后价值的因素，但对于那些未治愈患者中无转移生存期（MFI）的巨大差异，相对而言关注较少。在本文中，我们研究了247例接受乳腺癌根治性治疗但均发生转移的患者。MFI从2个月到22年不等，发现其取决于淋巴结状态、初始T分期，以及可能还取决于肿瘤在乳腺内的位置；它不取决于患者年龄或肿瘤的组织学表现。此外，从首次复发到死亡的时间与MFI无关。除了一个例外（脑转移），晚期复发者与早期复发者远处转移的初始部位相同。
