Blanco G, Holli K, Heikkinen M, Kallioniemi O P, Taskinen P
Department of Radiotherapy, Oulu University Central Hospital, Finland.
Br J Cancer. 1990 Jul;62(1):142-6. doi: 10.1038/bjc.1990.247.
Site of first recurrence, disease-free interval (DFI), female sex steroid receptors, ploidy measurements as well as histological grading have been analysed as potentially valuable predictive factors in 313 cases of recurrent breast cancer. Univariate and multivariate analyses show histological grading, site of recurrence and disease free interval to be useful prognostic variables when assessing prognosis once disease has recurred. High concentrations of oestrogen receptors (ER) were found in patients with bone metastases, whereas lower concentrations of ER were related to visceral recurrences. Ploidy measurements failed in this study to give any predictive information once disease recurred.
在313例复发性乳腺癌病例中，首次复发部位、无病生存期（DFI）、女性性激素受体、倍体测量以及组织学分级已被分析为潜在有价值的预测因素。单因素和多因素分析表明，在评估疾病复发后的预后时，组织学分级、复发部位和无病生存期是有用的预后变量。骨转移患者中发现雌激素受体（ER）浓度较高，而较低的ER浓度与内脏复发有关。在这项研究中，一旦疾病复发，倍体测量未能提供任何预测信息。
