免疫佐剂糖肽MDP（N-乙酰基-胞壁酰-L-丙氨酰-D-异谷氨酰胺）一些新类似物的合成
Synthesis of some new analogs of the immunoadjuvant glycopeptide MDP (N-acetyl-muramyl-L-alanyl-D-isoglutamine).
作者信息
Lefrancier P, Derrien M, Lederman I, Nief F, Choay J, Lederer E
出版信息
Int J Pept Protein Res. 1978 Apr;11(4):289-96. doi: 10.1111/j.1399-3011.1978.tb02851.x.
Abstract
In our continued efforts to elucidate the relationship between the structure and the immunoadjuvant, antiinfectious or mitogenic activity of N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), we report the synthesis of 11 new analogs. Five of them present some modifications in the N-acetyl-muramyl moiety.
摘要
在我们持续努力阐明N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）的结构与免疫佐剂、抗感染或促有丝分裂活性之间关系的过程中，我们报道了11种新类似物的合成。其中5种在N-乙酰胞壁酰部分有一些修饰。
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