Galelli A, Lefrancier P, Chedid L
Infect Immun. 1984 Nov;46(2):495-500. doi: 10.1128/iai.46.2.495-500.1984.
The in vivo induction of colony-stimulating activity (CSA) by N-acetylmuramyl-L-alanine-D-isoglutamine has been demonstrated recently. In this study we increased our understanding of this property by testing muramyl peptides of several structures and activities for their capacity to induce CSA in vivo. A comparison of the anti-infectious and adjuvant activities of these molecules revealed no correlation between the capacities of these compounds to be adjuvant active and to induce CSA: all adjuvant-inactive compounds induced CSA, and certain adjuvant-active molecules did not induce CSA. In contrast, all anti-infectious compounds induced CSA, but the reverse was not true; some compounds devoid of anti-infection activity were able to induce CSA only if they were adjuvant active.
最近已证实，N-乙酰胞壁酰-L-丙氨酸-D-异谷氨酰胺可在体内诱导集落刺激活性（CSA）。在本研究中，我们通过测试几种结构和活性的胞壁酰肽在体内诱导CSA的能力，加深了对这一特性的理解。对这些分子的抗感染活性和佐剂活性进行比较后发现，这些化合物作为佐剂的活性与其诱导CSA的能力之间没有相关性：所有无佐剂活性的化合物均可诱导CSA，而某些具有佐剂活性的分子则不能诱导CSA。相比之下，所有抗感染化合物均可诱导CSA，但反之则不然；一些没有抗感染活性的化合物只有在具有佐剂活性时才能诱导CSA。
