Kittleson M D, Eyster G E, Knowlen G G, Bari Olivier N, Anderson L K
J Am Vet Med Assoc. 1984 Feb 15;184(4):455-9.
Systolic myocardial function was assessed in 16 dogs with severe congestive heart failure due to chronic mitral valve fibrosis. End-systolic diameters were measured on echocardiograms and end-systolic volume indices were calculated. Thirteen of the 16 dogs (81%) had normal or only mildly abnormal myocardial function. These data suggested that myocardial failure is not a prominent factor contributing to signs of heart failure in dogs with mitral regurgitation. Because of these data, the routine use of digitalis glycosides to increase cardiac contractility is seriously questioned in dogs with heart failure secondary to chronic mitral regurgitation.
对16只因慢性二尖瓣纤维化导致严重充血性心力衰竭的犬进行了收缩期心肌功能评估。在超声心动图上测量收缩末期直径，并计算收缩末期容积指数。16只犬中有13只（81%）心肌功能正常或仅轻度异常。这些数据表明，心肌衰竭并非二尖瓣反流犬心力衰竭体征的主要促成因素。基于这些数据，对于继发于慢性二尖瓣反流的心力衰竭犬常规使用洋地黄苷来增强心肌收缩力受到了严重质疑。
