Walsh A, Haft D A, Miller M H, Loran M R, Friedman A H
Invest Ophthalmol Vis Sci. 1978 Jul;17(7):691-4.
Ocular penetration of 5-fluorocytosine (5FC) was studied in uninfected rabbits after subconjunctival and oral administration. With oral administration, 5FC achieved therapeutic levels in both the vitreous and aqueous humors. The use of a pharmacokinetic model permitted objective comparison of kinetic events within the eye chambers and the serum. The rates of entry and elimination in the vitreous were found to be slower than those in the aqueous, but the mean concentration over 24 hr was the same. The therapeutic levels achieved in the aqueous after subconjunctival administration were of shorter duration, and no detectable levels occurred in the vitreous. Oral administration is clearly therapeutically superior to subconjunctival administration in this model.
在未感染的兔子中，研究了结膜下给药和口服给药后5-氟胞嘧啶（5FC）的眼部渗透情况。口服给药后，5FC在玻璃体和房水中均达到治疗水平。药代动力学模型的使用使得能够客观比较眼房内和血清中的动力学事件。发现玻璃体中的进入和消除速率比房水中的慢，但24小时内的平均浓度相同。结膜下给药后房水中达到的治疗水平持续时间较短，玻璃体中未检测到药物水平。在该模型中，口服给药在治疗上明显优于结膜下给药。
