Reverdy M E, Freney J, Fleurette J, Coulet M, Surgot M, Marmet D, Ploton C
J Clin Microbiol. 1984 Feb;19(2):140-3. doi: 10.1128/jcm.19.2.140-143.1984.
Achromobacter xylosoxidans, a bacterial species named in 1971, is often isolated from aqueous environments, but little has been reported about its pathogenicity in humans, its epidemiological pattern, and its susceptibility to antibiotics and antiseptics. We were faced with an epidemic caused by this microorganism for 18 months in an intensive care unit. Two patients had fatal infections and 37 others were colonized. The source was the deionized water of the hemodialysis system. The 46 isolates were identified by comparison with the reference strain A. xylosoxidans ATCC 27061. The characteristic cellular fatty acids of this species were demonstrated by gas-liquid chromatography. The minimal inhibitory concentrations of 27 antibiotics were determined. The isolates were susceptible to only two: moxalactam at 4 micrograms/ml and ceftazidime at 8 micrograms/ml. The minimal bactericidal concentrations of one disinfectant and three antiseptics were: sodium hypochloride, 109 micrograms/ml; chlorhexidine digluconate in ethanol solution, 15 to 125 micrograms/ml; polyvinylpyrrolidone iodine, 750 micrograms/ml; and iodine ethanol, 312 to 625 micrograms/ml.
木糖氧化无色杆菌是1971年命名的一种细菌，常从水环境中分离得到，但关于其对人类的致病性、流行病学模式以及对抗生素和防腐剂的敏感性报道较少。在一个重症监护病房，我们面临了由这种微生物引起的长达18个月的疫情。两名患者发生致命感染，另外37人被定植。源头是血液透析系统的去离子水。通过与参考菌株木糖氧化无色杆菌ATCC 27061进行比较，鉴定出46株分离菌。通过气液色谱法证实了该菌种的特征性细胞脂肪酸。测定了27种抗生素的最低抑菌浓度。分离菌仅对两种抗生素敏感：头孢氧哌唑最低抑菌浓度为4微克/毫升，头孢他啶最低抑菌浓度为8微克/毫升。一种消毒剂和三种防腐剂的最低杀菌浓度分别为：次氯酸钠，109微克/毫升；乙醇溶液中的葡萄糖酸洗必泰，15至125微克/毫升；聚乙烯吡咯烷酮碘，750微克/毫升；碘乙醇，312至625微克/毫升。
