Variend S, Loughlin M A
J Clin Pathol. 1984 Mar;37(3):288-92. doi: 10.1136/jcp.37.3.288.
The presence of acetylcholinesterase in the tumour cells of neuroblastoma has been shown by enzyme histochemistry. For comparison, some other tumours likely to be found in children and commonly presenting histologically as small cell tumours have also been studied. Acetylcholinesterase activity was seen in rhabdomyosarcoma, but, compared with neuroblastoma, the activity was focal and sparse. One Ewing's tumour and a lymphoblastic lymphoma were negative for the enzyme reaction. Some of the ultrastructural features of neuroblastoma are correlated with the presence of this enzyme. Acetylcholinesterase enzyme histochemistry may provide a useful adjunct in the distinction of neuroblastoma from other small cell tumours.
酶组织化学已证实神经母细胞瘤的肿瘤细胞中存在乙酰胆碱酯酶。为作比较，还对一些儿童期可能出现且组织学上通常表现为小细胞肿瘤的其他肿瘤进行了研究。在横纹肌肉瘤中可见乙酰胆碱酯酶活性，但与神经母细胞瘤相比，其活性呈局灶性且稀少。1例尤因肉瘤和1例淋巴细胞性淋巴瘤的酶反应呈阴性。神经母细胞瘤的一些超微结构特征与这种酶的存在相关。乙酰胆碱酯酶组织化学可能有助于鉴别神经母细胞瘤与其他小细胞肿瘤。
