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神经母细胞瘤细胞中乙酰胆碱酯酶的调节

Regulation of acetylcholinesterase in neuroblastoma cells.

作者信息

Blume A, Gilbert F, Wilson S, Farber J, Rosenberg R, Nirenberg M

出版信息

Proc Natl Acad Sci U S A. 1970 Oct;67(2):786-92. doi: 10.1073/pnas.67.2.786.

DOI:10.1073/pnas.67.2.786
PMID:5289021
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283274/
Abstract

The specific activity of mouse neuroblastoma acetylcholinesterase (EC 3.1.1.7) increased 25-fold when the rate of cell division was restricted. The results show that acetylcholinesterase activity is regulated in neuroblastoma cells and that the regulatory mechanism is inversely related to the rate of cell division. Under the same conditions the specific activity of catechol-O-methyl transferase (EC 2.1.1.6) did not change significantly.

摘要

当小鼠神经母细胞瘤细胞的分裂速率受到限制时，其乙酰胆碱酯酶（EC 3.1.1.7）的比活性增加了25倍。结果表明，神经母细胞瘤细胞中的乙酰胆碱酯酶活性受到调节，且调节机制与细胞分裂速率呈负相关。在相同条件下，儿茶酚-O-甲基转移酶（EC 2.1.1.6）的比活性没有显著变化。

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Regulation of acetylcholinesterase in neuroblastoma cells.神经母细胞瘤细胞中乙酰胆碱酯酶的调节
Proc Natl Acad Sci U S A. 1970 Oct;67(2):786-92. doi: 10.1073/pnas.67.2.786.
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
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EFFECTS OF SPINAL CORD AND SUBSTRATE ON ACETYLCHOLINESTERASE IN CHICK EMBRYONIC SKELETAL MUSCLE.脊髓和底物对鸡胚骨骼肌中乙酰胆碱酯酶的影响。
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Counting actively metabolizing tissue cultured cells.计数活跃代谢的组织培养细胞。
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The effects of some acetylcholine derivatives on the cholinesterases of chick embryo intestine cultured in vitro.
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Two selective inhibitors of cholinesterase.两种胆碱酯酶选择性抑制剂。
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A direct radioisotopic assay for acetylcholinesterase.
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Regulation of axon formation by clonal lines of a neural tumor.神经肿瘤克隆系对轴突形成的调控。
Proc Natl Acad Sci U S A. 1970 May;66(1):160-7. doi: 10.1073/pnas.66.1.160.
8
Neuronal tumor cells with excitable membranes grown in vitro.在体外培养的具有可兴奋膜的神经元肿瘤细胞。
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1004-10. doi: 10.1073/pnas.64.3.1004.
9
Isolation of microtubule protein from cultured mouse neuroblastoma cells.从小鼠神经母细胞瘤细胞培养物中分离微管蛋白。
Proc Natl Acad Sci U S A. 1970 Jan;65(1):129-36. doi: 10.1073/pnas.65.1.129.
10
Establishment of functional clonal lines of neurons from mouse neuroblastoma.从小鼠神经母细胞瘤建立功能性神经元克隆系。
Proc Natl Acad Sci U S A. 1969 Sep;64(1):311-5. doi: 10.1073/pnas.64.1.311.