Lehrer S B, Barbandi F, Taylor J P, Salvaggio J E
J Allergy Clin Immunol. 1984 Feb;73(2):240-5. doi: 10.1016/s0091-6749(84)80014-7.
This study was undertaken to determine if there is an immunologic basis for reported tobacco-smoke hypersensitivity in man. Ninety-three individuals who were recruited on the basis of their smoking history and/or claimed sensitivity to tobacco smoke were skin prick tested with tobacco smoke and leaf extracts and their sera analyzed for reaginic and precipitating antibodies to these antigens. Results demonstrated that a significant number of the individuals who were tested had positive skin test and RAST responses to tobacco leaf antigens, whereas only a small number responded to smoke antigens. RAST or skin test responses of study subjects to leaf or smoke antigens did not correlate with symptoms of tobacco-smoke "sensitivity" or smoking history but did correlate with atopic status. Precipitins were detected only to tobacco leaf C in 46 of the 93 individuals who were tested but did not correlate with smoking history or smoke "sensitivity." These results suggest that subjective tobacco-smoke sensitivity is not caused by hypersensitivity to tobacco leaf or smoke antigens.
本研究旨在确定人类报告的烟草烟雾超敏反应是否存在免疫学基础。根据吸烟史和/或声称对烟草烟雾敏感招募了93名个体，用烟草烟雾和烟叶提取物对他们进行皮肤点刺试验，并分析他们的血清中针对这些抗原的反应素和沉淀抗体。结果表明，大量接受测试的个体对烟叶抗原的皮肤试验和放射性变应原吸附试验（RAST）反应呈阳性，而只有少数个体对烟雾抗原产生反应。研究对象对烟叶或烟雾抗原的RAST或皮肤试验反应与烟草烟雾“敏感”症状或吸烟史无关，但与特应性状态相关。在93名接受测试的个体中，仅在46名个体中检测到针对烟叶C的沉淀素，但这与吸烟史或烟雾“敏感性”无关。这些结果表明，主观的烟草烟雾敏感性并非由对烟叶或烟雾抗原的超敏反应所致。
