Lehrer S B, Wilson M R, Salvaggio J E
J Allergy Clin Immunol. 1978 Dec;62(6):368-70. doi: 10.1016/0091-6749(78)90138-0.
The immunogenic capacity of tobacco smoke or tobacco smoke in combination with host proteins to stimulate antibody production in rabbits was investigated. Several antisera from rabbits immunized with tobacco smoke components reacted by immunoprecipitation with tobacco smoke or leaf antigens. The serum precipitins were present only in immune sera and had electrophoretic mobility and molecular size identical to immunoglobulin. These results suggest that tobacco smoke contains components capable of stimulating an immune response in rabbits. It is possible that these components are immunogenic in man, although their role as allergens remains to be determined.
研究了烟草烟雾或烟草烟雾与宿主蛋白结合刺激兔产生抗体的免疫原性能力。用烟草烟雾成分免疫的兔产生的几种抗血清，通过免疫沉淀法与烟草烟雾或叶片抗原发生反应。血清沉淀素仅存在于免疫血清中，其电泳迁移率和分子大小与免疫球蛋白相同。这些结果表明，烟草烟雾含有能够刺激兔免疫反应的成分。尽管它们作为过敏原的作用尚待确定，但这些成分在人体中可能具有免疫原性。
