Serdula M K, Halstead S B, Wiebenga N H, Herrmann K L
JAMA. 1984 Apr 20;251(15):1974-7.
To document the serological response, 21 seronegative rubella vaccinees (hemagglutination inhibition [HI] titer less than 10) were revaccinated with RA 27/3 rubella vaccine. All demonstrated an anamnestic response. Although RA 27/3 vaccine was an effective booster, antibody boost was not maintained in some persons. Of 15 persons tested, 24 to 27 months after revaccination, six had a significant HI antibody drop (fourfold or greater); only one had lost all detectable HI antibody. Although all 21 study participants were initially HI seronegative by rubella HI testing, 16 (76.2%) possessed neutralization and/or enzyme-linked immunosorbent assay antibodies before revaccination. As more persons with vaccine-induced immunity join the adult population pool, more sensitive test methods may be needed to assess serological status accurately.
为记录血清学反应，对21名风疹血清学阴性接种者（血凝抑制[HI]效价低于10）再次接种RA 27/3风疹疫苗。所有人均表现出回忆反应。尽管RA 27/3疫苗是一种有效的加强疫苗，但部分人群的抗体增强未得以维持。在再次接种后24至27个月接受检测的15人中，6人出现HI抗体显著下降（四倍或更高）；只有1人失去了所有可检测到的HI抗体。尽管通过风疹HI检测，所有21名研究参与者最初均为HI血清学阴性，但16人（76.2%）在再次接种前就已拥有中和及/或酶联免疫吸附测定抗体。随着越来越多具有疫苗诱导免疫力的人加入成年人群体，可能需要更敏感的检测方法来准确评估血清学状态。
