Asahi T, Ueda K, Hidaka Y, Miyazaki C, Tanaka Y, Nishima S
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Vaccine. 1997 Nov;15(16):1791-5. doi: 10.1016/s0264-410x(97)00114-x.
Twenty-six institutionalized children immunized with a Japanese rubella vaccine, Matsuba strain, have been observed for 23 years and the persistence of vaccine-induced rubella immunity documented. All vaccinees were shown to have seroconverted to rubella virus in a haemagglutination inhibition (HI) test, and the geometric mean titre (GMT) of rubella HI antibody rose to 2 5-8 months after vaccination (Ueda et al., Acta Paediatrica Japonica, Overseas Edition 1978, 20, 8-14). The GMT then declined gradually to 2 23 years after inoculation, except in four cases (15.4%) which had reverted to negative. However, three of the four maintained a rubella HI antibody titre of 1:4. Twelve of the 26 vaccinees were revaccinated 24 years after primary vaccination, and all ten cases having initial titres of < or = 1:16 demonstrated secondary responses. Rubella immunity induced by vaccination had persisted, so routine booster immunization did not seem necessary. However, a second immunization programme should be considered to achieve high antibody-positive rates and to protect against primary vaccine failure.
对26名接种日本风疹疫苗松叶株的福利院儿童进行了23年的观察，并记录了疫苗诱导的风疹免疫力的持久性。所有接种者在血凝抑制（HI）试验中均显示风疹病毒血清学转换，风疹HI抗体的几何平均滴度（GMT）在接种后2至5 - 8个月升至2。（上田等人，《日本儿科学会杂志》海外版，1978年，20卷，8 - 14页）。然后，GMT在接种后23年逐渐下降，除了4例（15.4%）转为阴性。然而，这4例中的3例风疹HI抗体滴度维持在1:4。26名接种者中有12名在初次接种24年后再次接种，所有初始滴度≤1:16的10例均表现出二次反应。接种诱导的风疹免疫力持续存在，因此常规加强免疫似乎没有必要。然而，应考虑实施第二次免疫计划，以实现高抗体阳性率并预防原发性疫苗失败。
