Demurov E A, Mil'chakov V I, Gerasimov A M
Kardiologiia. 1984 Jan;24(1):67-70.
A session of hyperbaric oxygenation (HBO) at 2.5 at. abs. conducted for one hour in rabbits with adrenalin heart affection (AHA) immediately after adrenalin administration prevented a decrease in the cardiac contractile function usually developing within two hours after AHA. On the third day of the follow up, rabbits with AHA receiving daily HBO displayed a decrease in the pump and contractile functions as well as in superoxide dismutase (SOD) activity and the antioxidant activity (AOA) of the left ventricle lipids. Combination of HBO sessions with the intra-muscular administration of alpha-tocopherol (50 mg/kg) made the decrease in SOD activity less pronounced and prevented both the fall in lipid AOA and the depression of the heart contractile and pump functions on the third day following AHA. It is suggested that the combined use of HBO and substances increasing the potency of the cell antioxidation system may become one of the principles of reducing HBO side effects and of expanding the potentialities of HBO in treating ischemic and adrenergic heart impairments.
对患有肾上腺素性心脏病变（AHA）的家兔在注射肾上腺素后立即进行1小时的2.5个绝对大气压的高压氧治疗（HBO），可防止通常在AHA后两小时内出现的心脏收缩功能下降。在随访的第三天，接受每日HBO治疗的AHA家兔的泵血和收缩功能以及左心室脂质的超氧化物歧化酶（SOD）活性和抗氧化活性（AOA）均有所下降。HBO治疗与肌肉注射α-生育酚（50mg/kg）相结合，使SOD活性的下降不那么明显，并防止了AHA后第三天脂质AOA的下降以及心脏收缩和泵血功能的抑制。有人认为，联合使用HBO和增强细胞抗氧化系统效能的物质可能成为减少HBO副作用以及扩大HBO在治疗缺血性和肾上腺素能性心脏损伤方面潜力的原则之一。
