Aliev M A, Bekbolotova A K, Kostiuchenko L S, Lemeshenko V A
Kardiologiia. 1989 Sep;29(9):77-81.
Epinephrine-induced cardiac injury (ECI) was simulated in rabbits. The indices of the system of peroxidation of lipids (LPO) and antioxidants were examined during various periods (3 hours, 3 and 9 days) of ECI. It was found that lower lipid antioxidative activity of blood, i.e. weaker body's antiperoxide protection, was found most early, then there was higher malonic dialdehyde (MDA) (a marker of thromboxane, TBA2) generation. The increase in antiperoxidase protection occurred at the level of the target organ (heart). There was a rise in the activity of the antioxidative enzyme superoxide dismutase and inhibited formation of primary products of LPO such as dien conjugates from early to 9 hours of the observation. When the natural antioxidant alpha-tocopherol was given prior to ECI, it prevented enhanced MDA formation in the platelets, optimized prostacyclin synthesis in the vascular wall, and stabilized blood lipid antioxidative activity.
在兔子身上模拟了肾上腺素诱导的心脏损伤（ECI）。在ECI的不同时期（3小时、3天和9天）检测脂质过氧化（LPO）系统和抗氧化剂的指标。结果发现，血液中脂质抗氧化活性较低，即机体的抗过氧化物保护较弱，最早出现，随后丙二醛（MDA）（血栓素的标志物，TBA2）生成增加。抗过氧化物酶保护的增加发生在靶器官（心脏）水平。从观察开始的早期到9小时，抗氧化酶超氧化物歧化酶的活性增加，LPO初级产物如二烯共轭物的形成受到抑制。在ECI之前给予天然抗氧化剂α-生育酚，可防止血小板中MDA形成增加，优化血管壁中前列环素的合成，并稳定血脂抗氧化活性。
