Demurov E A, Vinnitskiĭ L I, Vasil'eva N N, Vorob'eva N T, Koloskov Iu B
Kardiologiia. 1982;22(6):50-4.
Two hours after the ligation of the descending branch of the left coronary artery in rabbits the contractile function of the heart decreased, concentration of phosphocreatine, ATP, glycogen dropped, and the content of lactic acid in the ischaemic and intact areas of the left ventricle elevated. Two-hour ischaemia of the myocardium was accompanied by increase of the cAMP and decrease of cGMP levels in the ischaemic and intact areas. Hyperbaric oxygenation (HBO, 2 at. abs, 1 h) started 30-40 min after coronary occlusion led to partial restoration of the cardiac contractility function, improvement of the energy and carbohydrate metabolism in the ischaemic and intact areas of the left ventricle and prevented cardiac fibrillation. It is surmised that favourable action of HBO on the functional state of the heart in its acute focal ischaemia is related not only to the antihypoxic effect but also to the rearrangement of the system of neurohormonal control of the heart.
家兔左冠状动脉降支结扎两小时后，心脏收缩功能下降，磷酸肌酸、三磷酸腺苷、糖原浓度降低，左心室缺血区和非缺血区乳酸含量升高。心肌两小时缺血伴随着缺血区和非缺血区环磷酸腺苷水平升高和环磷酸鸟苷水平降低。冠状动脉闭塞后30 - 40分钟开始进行高压氧治疗（HBO，2个绝对大气压，1小时），可使心脏收缩功能部分恢复，改善左心室缺血区和非缺血区的能量及碳水化合物代谢，并预防心脏纤颤。据推测，高压氧对急性局灶性缺血心脏功能状态的有利作用不仅与抗缺氧作用有关，还与心脏神经激素控制系统的重新调整有关。
