Gray B A, McCaffree D R, Sivak E D, McCurdy H T
J Appl Physiol Respir Environ Exerc Physiol. 1978 Jul;45(1):119-27. doi: 10.1152/jappl.1978.45.1.119.
The immediate effects of pulmonary vascular engorgement (PVE) on lung and chest wall mechanics were studied in anesthetized, paralyzed dogs with the chest wall intact. A balloon-tipped catheter advanced retrograde into the left atrium was used to produce partial mitral valve obstruction and increases in pulmonary artery and left atrial preassures equal to 15 and 20 cm H2O, respectively. This increased pulmonary blood volume (PBV) by 50% and reduced dynamic lung ocmplicance 14%. With the airway occluded at different lung volumes, transient PVE produced a 6% decrease in compliance on the deflation limb of the pressure volume curve of the lung and a shift in the chest wall pressure-volume curve, which was consistent with an increase in chest wall volume equal to the increase in PBV. During apnea with the airway open, PVE reduced lung gas volume and increased chest wall recoil. We conclude that the changes in chest wall recoil associated with PVE are the result of an increase in total lung displacement volume.
在胸壁完整的麻醉、麻痹犬中研究了肺血管充血（PVE）对肺和胸壁力学的即时影响。将一根带球囊的导管逆行插入左心房，用于造成部分二尖瓣梗阻，并使肺动脉和左心房压力分别升高至15和20 cm H₂O。这使肺血容量（PBV）增加了50%，动态肺顺应性降低了14%。在不同肺容量下气道阻塞时，短暂的PVE使肺压力-容量曲线放气支的顺应性降低了6%，并使胸壁压力-容量曲线发生移位，这与胸壁容积增加量等于PBV增加量一致。在气道开放的呼吸暂停期间，PVE减少了肺气体容积并增加了胸壁回缩力。我们得出结论，与PVE相关的胸壁回缩力变化是肺总移位容积增加的结果。
