Beck W, Stubbe P
Monatsschr Kinderheilkd. 1984 Jan;132(1):32-7.
The purpose of this study was to provide a medical alternative to mastectomy in boys with excessive breast development. Eleven boys with bilateral gynecomastia, ranging in size between 9 X 7 cm and 3 X 3 cm in diameter, were treated with 200 mg of Danazol daily for 6 months. This therapy led to a reduction in breast size between 3 X 3 cm and 1,5 X 1,5 cm. The antigonadotropic action of Danazol was documented by inhibition of basal gonadotropin secretion, by disappearance of normal sleep dependent rhythms and by a reduced pituitary response to stimulation. Simultaneously, plasma testosteron secretion was suppressed without reduction of testicular volumes. In all patients the hypothalamo-pituitary gonadal axis normalized within 67 months after termination of therapy and no relapse was observed over a control period up to 26 months. The continuing regression after Danazol treatment emphasizes the effectiveness of drug therapy as an alternative regimen to surgical intervention.
本研究的目的是为乳腺过度发育的男孩提供一种替代乳房切除术的医学治疗方法。11名患有双侧乳腺增生的男孩，其乳房直径大小在9×7厘米至3×3厘米之间，每天服用200毫克达那唑，持续6个月。该治疗使乳房尺寸缩小至3×3厘米至1.5×1.5厘米之间。达那唑的抗促性腺激素作用通过以下方面得到证实：抑制基础促性腺激素分泌、正常睡眠依赖性节律消失以及垂体对刺激的反应降低。同时，血浆睾酮分泌受到抑制，但睾丸体积未减小。在所有患者中，治疗终止后6至7个月下丘脑 - 垂体 - 性腺轴恢复正常，在长达26个月的对照期内未观察到复发。达那唑治疗后的持续消退强调了药物治疗作为手术干预替代方案的有效性。
