Ferenczy A, Gelfand M M
Obstet Gynecol. 1984 Mar;63(3):295-302.
The endometrium was sampled in the office with the Endocyte, a disposable plastic brush. The aim of the study was to assess its clinical characteristics and diagnostic yield with respect to cytology and histology. One hundred eighty of the 200 women sampled were 46 years and older, and 65.5% of them were asymptomatic but at risk for corpus carcinoma. In every case, brushing was controlled by subsequent biopsy. Brushing was safe, fast, and simple. Patient acceptance for future tests with Endocyte was 100%, compared to 40% with biopsy. Satisfactory samples for cytologic diagnosis were obtained in 92% of the patients with brushing and in 90% with biopsy-obtained histology. Endocyte cytology confirmed biopsy-proved hyperplasia (36 cases) and carcinoma (two cases) in 80.5 and 100% of the cases, respectively; 19.5% of hyperplasias were underdiagnosed as normal endometrium. No false-positive diagnosis was made. Fifty percent of mini-biopsies with the Endocyte were unsatisfactory for diagnosis. The results indicate that, provided endometrial cytologic expertise is available, the Endocyte is useful for screening asymptomatic women at risk for endometrial carcinoma and its precursors.
使用一次性塑料刷Endocyte在门诊采集子宫内膜样本。本研究的目的是评估其在细胞学和组织学方面的临床特征及诊断效能。200例接受采样的女性中，180例年龄在46岁及以上，其中65.5%无症状但有子宫内膜癌风险。在每例病例中，刷取样本后均进行后续活检以对照。刷取操作安全、快速且简单。与活检40%的接受率相比，患者对未来使用Endocyte进行检测的接受率为100%。刷取样本的患者中92%获得了满意的细胞学诊断样本，活检获取组织学样本的患者中90%获得了满意样本。Endocyte细胞学分别在80.5%和100%的病例中确诊了活检证实的增生（36例）和癌（2例）；19.5%的增生被误诊为正常子宫内膜。未出现假阳性诊断。使用Endocyte进行的微型活检有50%诊断不满意。结果表明，若有子宫内膜细胞学专业技术人员，Endocyte可用于筛查有子宫内膜癌及其前驱病变风险的无症状女性。
