西多霉素因子5在C-3'位的修饰。

Modification of seldomycin factor 5 at C-3'.

作者信息

Carney R E, McAlpine J B, Jackson M, Stanaszek R S, Washburn W H, Cirovic M, Mueller S L

出版信息

J Antibiot (Tokyo). 1978 May;31(5):441-50. doi: 10.7164/antibiotics.31.441.

DOI:10.7164/antibiotics.31.441

Abstract

Attempted removal of the 3'-hydroxyl group of seldomycin factor 5 via displacement of a sulfonate ester has led to 3'-epi-seldomycin factor 5. Removal of the hydroxyl group has been effected by the Barton procedure. The antibacterial activity of 3'-epi- and 3'-deoxyseldomycin factor 5 against various aminoglycoside-resistant strains is discussed.

摘要

通过磺酸酯的取代反应尝试去除塞尔多霉素因子5的3'-羟基，得到了3'-表-塞尔多霉素因子5。羟基的去除是通过巴顿方法实现的。讨论了3'-表-和3'-脱氧塞尔多霉素因子5对各种氨基糖苷类耐药菌株的抗菌活性。