一种新的氨基糖苷类抗生素复合物——塞尔多霉素。II. 分离、理化性质及色谱特性。

A new aminoglycoside antibiotic complex--the seldomycins. II. Isolation, physicochemical and chromatographic properties.

作者信息

Sato S, Takasawa S, Sato T, Yamamoto M, Okachi R

出版信息

J Antibiot (Tokyo). 1977 Jan;30(1):25-30. doi: 10.7164/antibiotics.30.25.

DOI:10.7164/antibiotics.30.25

Abstract

An antibiotic complex consisting of four components, seldomycin factors 1, 2, 3 and 5 was isolated from the fermentation broth of Streptomyces hofunensis sp. nov. by use of a cationic exchange resin. After silica gel column chromatography, the purified components were characterized as new aminoglycoside antibiotics by their physicochemical, chromatographic and antimicrobial properties.

摘要

利用阳离子交换树脂从新种霍夫链霉菌的发酵液中分离出一种由四种成分组成的抗生素复合物，即塞尔多霉素因子1、2、3和5。经硅胶柱色谱法分离后，根据其物理化学性质、色谱性质和抗菌特性，将纯化后的成分鉴定为新型氨基糖苷类抗生素。