一种新的氨基糖苷类抗生素复合物——塞尔多霉素。III. 塞尔多霉素因子1和2+的结构。

A new aminoglycoside antibiotic complex--the seldomycins. III. The structures of seldomycin factors 1 and 2+.

作者信息

Egan R S, Sinclair A C, De Vault R L, McAlpine J B, Mueller S L, Goodley P C, Stanaszek R S, Cirovic M, Mauritz R J, Mitscher L A, Shirahata K, Sato S, Iida T

出版信息

J Antibiot (Tokyo). 1977 Jan;30(1):31-8. doi: 10.7164/antibiotics.30.31.

DOI:10.7164/antibiotics.30.31

PMID:838630

Abstract

The structures of seldomycin factors 1 and 2 have been determined by consideration of chemical degradation and spectral properties. Factor 1, also known as XK-88-1, is shown to be 6-O-(2-amino-2-deoxy-alpha-D-xylopyranosyl) paromamine (1) and factor 2, also known as XK-88-2, is shown to be 4'-deoxy-neamine (2). Mass spectral evidence has been obtained that suggests the most probable structure for seldomycin factor 3, also known as XK-88-3, is 6'-amino-6'-deoxyseldomycin factor 1 (12).

摘要

通过对化学降解和光谱性质的研究，确定了塞尔多霉素因子1和因子2的结构。因子1，也称为XK-88-1，被证明是6-O-(2-氨基-2-脱氧-α-D-吡喃木糖基)巴龙胺(1)，而因子2，也称为XK-88-2，被证明是4'-脱氧-新霉素胺(2)。已获得质谱证据，表明塞尔多霉素因子3（也称为XK-88-3）最可能的结构是6'-氨基-6'-脱氧塞尔多霉素因子1(12)。