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蛔虫两种主要核糖体DNA大小类别的染色体排列

Chromosomal arrangement of the two main rDNA size classes of Ascaris lumbricoides.

作者信息

Back E, Felder H, Müller F, Tobler H

出版信息

Nucleic Acids Res. 1984 Feb 10;12(3):1333-47. doi: 10.1093/nar/12.3.1333.

DOI:10.1093/nar/12.3.1333
PMID:6701086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC318580/
Abstract

The two main rDNA size classes of 8.8 kb and 8.4 kb length from Ascaris lumbricoides, which comprise more than 95% of the total nuclear rDNA, are arranged as internally homogeneous clusters and are not intermingled with each other. The rRNA genes are present on a single autosomal locus as could be demonstrated by in situ hybridization of fluorochrome-labelled 18S and 26S rRNA to metaphase chromosomes of spermatocytes I. The quantitative ratio of the two rDNA size classes varies largely between individuals being on the average roughly 10:1 in the investigated wild population of A. lumbricoides. However, there are no differences in the hybridization pattern of the two rDNAs in the DNA eliminating nematode A. lumbricoides between germ line and somatic cells in any of the individuals that have been analyzed.

摘要

来自蛔虫的两种主要rDNA大小类别，长度分别为8.8 kb和8.4 kb，占总核rDNA的95%以上，它们排列成内部均匀的簇，彼此不混杂。rRNA基因位于单个常染色体位点上，这可以通过用荧光染料标记的18S和26S rRNA与精母细胞I的中期染色体进行原位杂交来证明。在被研究的野生蛔虫种群中，这两种rDNA大小类别的定量比例在个体之间差异很大，平均约为10:1。然而，在已分析的任何个体中，DNA消除线虫蛔虫的两种rDNA在生殖细胞和体细胞中的杂交模式没有差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/f26db0072497/nar00321-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/c2871294bd65/nar00321-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/a34eb6962403/nar00321-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/7b2a2b0c75f1/nar00321-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/fcf82298dc2c/nar00321-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/f26db0072497/nar00321-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/c2871294bd65/nar00321-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/a34eb6962403/nar00321-0052-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/7b2a2b0c75f1/nar00321-0053-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/fcf82298dc2c/nar00321-0055-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae9e/318580/f26db0072497/nar00321-0056-a.jpg

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本文引用的文献

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The ribosomal DNA of Calliphora erythrocephala. The cistron classes of total genomic DNA.红头丽蝇的核糖体DNA。总基因组DNA的顺反子类别。
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Ribosomal RNA genes with an intervening sequence are clustered within the X chromosomal ribosomal DNA of Drosophila hydei.带有间隔序列的核糖体RNA基因聚集在海德氏果蝇的X染色体核糖体DNA内。
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蛔虫核糖体DNA两种主要大小类别的体内和体外转录起始位点的定位及侧翼序列的比较分析。
Nucleic Acids Res. 1987 Aug 25;15(16):6515-38. doi: 10.1093/nar/15.16.6515.
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Type I-like intervening sequences are found in the rDNA of the nematode Ascaris lumbricoides.在蛔虫的核糖体DNA中发现了类似I型的间隔序列。
Nucleic Acids Res. 1987 Oct 12;15(19):7689-707. doi: 10.1093/nar/15.19.7689.
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The two main rDNA size classes of Ascaris lumbricoides: comparison of transcription termination and spacer organization.蛔虫的两种主要核糖体DNA大小类别：转录终止与间隔区组织的比较
Nucleic Acids Res. 1992 Jun 25;20(12):2977-83. doi: 10.1093/nar/20.12.2977.
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The ribosomal DNA of Drosophila melanogaster is organized differently from that of Drosophila hydei.黑腹果蝇的核糖体DNA的组织方式与海德氏果蝇不同。
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