视黄醇在阿诺德-奇亚里畸形发生中的剂量-反应关系。

Dose-response relationships of retinol in production of the Arnold-Chiari malformation.

作者信息

Willhite C C

出版信息

Toxicol Lett. 1984 Mar;20(3):257-62. doi: 10.1016/0378-4274(84)90157-7.

PMID:6701913

Abstract

A single oral dose of 5000, 10 000, 15 000, 20 000 or 30 000 I.U. vitamin A alcohol (retinol) on the eighth day of gestation in the pregnant hamster resulted in the production of the Arnold-Chiari malformation types I and II in 0, 6.6, 57, 56 and 85%, respectively, of all fetuses examined. The pattern and severity of the malformations of the chondrocranium and viscerocranium changed as the dose of retinol was increased. The smallest dose of retinol used in the present study which induced gross terata in hamsters was approximately 11 times greater than the highest oral daily dose of retinol used in clinical cancer chemoprevention trials.

摘要

在妊娠仓鼠妊娠第8天单次口服5000、10000、15000、20000或30000国际单位的维生素A醇（视黄醇），在所检查的所有胎儿中，分别有0%、6.6%、57%、56%和85%出现了I型和II型阿诺德-奇阿利畸形。随着视黄醇剂量的增加，软骨颅和脏颅畸形的模式和严重程度发生了变化。本研究中在仓鼠身上诱导出明显畸形的视黄醇最小剂量约为临床癌症化学预防试验中使用的视黄醇最高每日口服剂量的11倍。