Käär M L, Akerblom H K, Huttunen N P, Knip M, Säkkinen K
Acta Paediatr Scand. 1984 Jan;73(1):102-8. doi: 10.1111/j.1651-2227.1984.tb09906.x.
The metabolic control, assessed from the mean daily glucosuria, mean daily glucosuria index based on home tests, and mean haemoglobin A1 (HbA1) concentrations during 1980, and the influence of various factors on the control were analysed in 177 diabetic children and adolescents. The mean daily glucosuria was 21% of the carbohydrates in the subscribed diet, and the mean glucosuria index 55%. The mean HbA1 was 14.0%. Boys had better metabolic control than girls. Good motivation towards treatment was associated with better metabolic control. There was a negative correlation between metabolic control and both the age of the child and the duration of diabetes. Prepubertal children were better controlled than those in puberty. Adherence to the dietary regimen was related to better control, as was the patient's endogenous insulin secretion, measured by serum C-peptide concentration. There was also an association between the season and the metabolic control, the control being better in the spring than during the other seasons. On the basis of these results male sex, a good motivation towards treatment, residual beta-cell function and adherence to the prescribed diet favor good metabolic control, while a long duration of the disease, the presence of puberty and relatively high age in childhood are factors impairing the metabolic control.
根据1980年期间的平均每日糖尿量、基于家庭测试的平均每日糖尿指数以及平均血红蛋白A1（HbA1）浓度评估代谢控制情况，并分析了177名糖尿病儿童和青少年中各种因素对代谢控制的影响。平均每日糖尿量占规定饮食中碳水化合物的21%，平均糖尿指数为55%。平均HbA1为14.0%。男孩的代谢控制比女孩更好。对治疗的良好动机与更好的代谢控制相关。代谢控制与儿童年龄和糖尿病病程均呈负相关。青春期前儿童的控制情况优于青春期儿童。坚持饮食方案与更好的控制相关，通过血清C肽浓度测量的患者内源性胰岛素分泌情况也是如此。季节与代谢控制之间也存在关联，春季的控制情况优于其他季节。基于这些结果，男性、对治疗的良好动机、残余β细胞功能以及坚持规定饮食有利于良好的代谢控制，而病程长、青春期的存在以及儿童相对较高的年龄是损害代谢控制的因素。
