Church N R, Anas N G, Hall C B, Brooks J G
Am J Dis Child. 1984 Mar;138(3):247-50. doi: 10.1001/archpedi.1984.02140410027010.
Medical records of 261 hospitalized patients less than 1 year old with documented respiratory syncytial virus (RSV) infection were reviewed to determine the incidence of RSV-associated apnea and the accompanying risk of subsequent apnea or death. Apnea in association with RSV infection occurred in 18% of the infants. Premature birth and a young postnatal age were risk factors for development of apnea with RSV disease. Apnea of prematurity appeared to be a significant risk factor for RSV apnea development in infants with a gestational age of 32 weeks or less at birth, but infants with RSV apnea did not appear to be at risk for subsequent apnea. These results suggested that in hospitalized infants, RSV apnea may be related to immaturity of respiratory drive. Two of the 48 infants with RSV apnea subsequently died during the first year of life.
回顾了261例年龄小于1岁、有呼吸道合胞病毒（RSV）感染记录的住院患儿的病历，以确定RSV相关呼吸暂停的发生率以及随后发生呼吸暂停或死亡的伴随风险。18%的婴儿出现了与RSV感染相关的呼吸暂停。早产和出生后年龄小是RSV疾病发生呼吸暂停的危险因素。出生时胎龄32周或更小的婴儿，早产呼吸暂停似乎是RSV呼吸暂停发生的一个重要危险因素，但患有RSV呼吸暂停的婴儿似乎没有随后发生呼吸暂停的风险。这些结果表明，在住院婴儿中，RSV呼吸暂停可能与呼吸驱动不成熟有关。48例患有RSV呼吸暂停的婴儿中有2例在生命的第一年随后死亡。
