Meert K, Heidemann S, Abella B, Sarnaik A
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
Crit Care Med. 1990 Dec;18(12):1357-9. doi: 10.1097/00003246-199012000-00009.
We compared previously healthy prematurely born infants with full-term infants hospitalized with respiratory syncytial virus (RSV) infection to evaluate the role of prematurity on the clinical course of the illness. During a 5-yr period (1984 to 1989), 484 previously healthy patients were admitted to the hospital with RSV infection. No differences were found in the presenting symptoms of respiratory distress, cough, fever or shock, although the premature group was more likely to present with apnea (p less than .001). Chest roentgenograms revealed that premature infants had a higher incidence of atelectasis/infiltrate and hyperinflation (p less than .05). Premature infants had longer hospital stays as well as a higher Physiologic Stability Index and Therapeutic Intervention Score (p less than .001). They were also more likely to receive supplemental oxygen, ICU admission, mechanical ventilation, and nothing by mouth status (p less than .001). We conclude that premature birth increases the risk of more severe and prolonged RSV disease.
我们将先前健康的早产婴儿与因呼吸道合胞病毒（RSV）感染而住院的足月儿进行比较，以评估早产在该疾病临床病程中的作用。在1984年至1989年的5年期间，484名先前健康的患者因RSV感染入院。在呼吸窘迫、咳嗽、发热或休克等初始症状方面未发现差异，尽管早产组更易出现呼吸暂停（p<0.001）。胸部X线片显示，早产儿肺不张/浸润和肺过度充气的发生率更高（p<0.05）。早产儿住院时间更长，生理稳定性指数和治疗干预评分也更高（p<0.001）。他们也更有可能接受补充氧气、入住重症监护病房、机械通气以及禁食（p<0.001）。我们得出结论，早产会增加患更严重和更持久RSV疾病的风险。
