Sadeghi S B, Hsieh E W, Gunn S W
Am J Obstet Gynecol. 1984 Mar 15;148(6):726-9. doi: 10.1016/0002-9378(84)90555-6.
One of the largest nationally reported cases of carcinoma in situ in the teenage population of the United States is based on 1 year's computerized data from Cancer Screening Services. In 1981, 796,337 women were screened with an average age of 25.9. Of these, 18,589 (2.33%) had abnormal cytology. In 194,069 (24.3%) of the 796,337 patients aged 15 to 19, 3,651 (1.9%) had abnormal cytology. In 17% of all patients with abnormal cytology biopsy of the cervix was performed. The prevalence rate of dysplasia and carcinoma in situ was 18.8/1,000 for ages 15 to 19 and 28.8/1,000 for ages 20 to 24. Biopsy-proved cases of all grades of cervical intraepithelial neoplasia in the teenage population indicates a prevalence of 13.3/1,000. Sixty cases of grade 3 cervical intraepithelial neoplasia (carcinoma in situ) were diagnosed by biopsy in the teenage population for a projected prevalence rate of 2.6/1,000. No invasive squamous cell carcinoma was found in this age group. This emphasizes the importance of cervical intraepithelial neoplasia as a developing medical and public health problem in this age group and indicates that teenagers of any "permissive society" should be considered as "high risk" and included in screening programs.
美国全国报告的青少年原位癌最大规模病例之一是基于癌症筛查服务机构一年的计算机化数据。1981年,对796,337名女性进行了筛查,平均年龄为25.9岁。其中,18,589名(2.33%)女性细胞学检查异常。在796,337名年龄在15至19岁的患者中,有194,069名(24.3%),其中3,651名(1.9%)细胞学检查异常。在所有细胞学检查异常的患者中,17%进行了宫颈活检。15至19岁的发育异常和原位癌患病率为18.8/1000,20至24岁为28.8/1000。活检证实的青少年人群中所有级别的宫颈上皮内瘤变患病率为13.3/1000。通过活检在青少年人群中诊断出60例3级宫颈上皮内瘤变(原位癌),预计患病率为2.6/1000。该年龄组未发现浸润性鳞状细胞癌。这强调了宫颈上皮内瘤变作为该年龄组一个日益严重的医学和公共卫生问题的重要性,并表明任何“宽容社会”的青少年都应被视为“高危人群”并纳入筛查项目。