人类血小板中血清素和多巴胺的一种常见摄取系统。
A common uptake system for serotonin and dopamine in human platelets.
作者信息
Omenn G S, Smith L T
出版信息
J Clin Invest. 1978 Aug;62(2):235-40. doi: 10.1172/JCI109121.
Abstract
Kinetic and pharmacologic properties of uptake of serotonin and dopamine by normal human platelets have been investigated to test whether platelets can be employed as a model system for the reuptake of serotonin and dopamine in brain. Uptake of serotonin into platelets closely resembles reuptake of serotonin into serotonergic neurons. In contrast, uptake of dopamine into platelets appears to be mediated inefficiently via the specific serotonin uptake mechanism, based upon several lines of evidence. Serotonin and dopamine compete with each other, Antidepressant drugs, which are competitive inhibitors of uptake of both of these neurotransmitters, act at the same concentration of drug despite large differences in the Km values. Serotonin antagonists inhibit both serotonin and dopamine uptake. Finally, a serotonin-specific uptake inhibitor (fluoxetine) blocks dopamine, as well as serotonin, uptake.
摘要
已经对正常人血小板摄取5-羟色胺和多巴胺的动力学及药理学特性进行了研究，以测试血小板是否可作为大脑中5-羟色胺和多巴胺再摄取的模型系统。血小板摄取5-羟色胺与5-羟色胺能神经元摄取5-羟色胺非常相似。相比之下，基于多方面证据，血小板摄取多巴胺似乎是通过特定的5-羟色胺摄取机制低效介导的。5-羟色胺和多巴胺相互竞争，抗抑郁药物是这两种神经递质摄取的竞争性抑制剂，尽管它们的Km值有很大差异，但在相同药物浓度下起作用。5-羟色胺拮抗剂抑制5-羟色胺和多巴胺的摄取。最后，一种5-羟色胺特异性摄取抑制剂（氟西汀）可阻断多巴胺以及5-羟色胺的摄取。
相似文献
1
A common uptake system for serotonin and dopamine in human platelets.人类血小板中血清素和多巴胺的一种常见摄取系统。
J Clin Invest. 1978 Aug;62(2):235-40. doi: 10.1172/JCI109121.
2
3
4
The effects of prodipine and budipine on 14C-5-hydroxytryptamine uptake and release by human blood platelets.丙酯心安和布地品对人血小板摄取及释放14C - 5 - 羟色胺的影响。
Arzneimittelforschung. 1980;30(7):1129-34.
5
5-Hydroxytryptamine and dopamine transport by rat and human blood platelets.大鼠和人血小板对5-羟色胺和多巴胺的转运
Br J Pharmacol. 1978 Feb;62(2):219-26. doi: 10.1111/j.1476-5381.1978.tb08449.x.
6
Pharmacologic properties of serotonergic agents and antidepressant drugs.血清素能药物和抗抑郁药的药理学特性。
J Clin Psychiatry. 1987 Mar;48 Suppl:5-11.
7
Prolonged treatment with the specific 5-HT-uptake inhibitor citalopram: effect on dopaminergic and serotonergic functions.使用特异性5-羟色胺摄取抑制剂西酞普兰进行长期治疗：对多巴胺能和5-羟色胺能功能的影响。
Pol J Pharmacol Pharm. 1984 Mar-Jun;36(2-3):221-30.
8
Active [3H]-dopamine uptake displayed by native lymphocyte suspensions is mainly due to contaminating platelets.天然淋巴细胞悬液所显示的活性[3H] - 多巴胺摄取主要归因于污染的血小板。
Pharmacopsychiatry. 1998 Sep;31(5):193-8. doi: 10.1055/s-2007-979326.
9
Antidepressants and the serotonin uptake in platelets.抗抑郁药与血小板中的血清素摄取。
Acta Psychiatr Scand Suppl. 1980;280:111-9.
10
Tryptamine, a substrate for the serotonin transporter in human platelets, modifies the dissociation kinetics of [3H]imipramine binding: possible allosteric interaction.色胺是人类血小板中血清素转运体的一种底物，它会改变[3H]丙咪嗪结合的解离动力学：可能存在变构相互作用。
J Neurochem. 1985 Feb;44(2):349-56. doi: 10.1111/j.1471-4159.1985.tb05423.x.
引用本文的文献
1
Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells.在绒毛滋养层分化过程中单胺转运系统的功能重排：原发性人滋养层细胞与 BeWo 细胞之间明显差异的证据。
Reprod Biol Endocrinol. 2022 Aug 4;20(1):112. doi: 10.1186/s12958-022-00981-8.
2
Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery.工程化人血小板衍生微粒作为靶向药物递送的天然载体。
Oncotarget. 2019 Oct 8;10(56):5835-5846. doi: 10.18632/oncotarget.27223.
3
Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation?外周脑源性神经营养因子水平的变化是否与血小板激活有关？
World J Psychiatry. 2016 Mar 22;6(1):84-101. doi: 10.5498/wjp.v6.i1.84.
4
Fluoxetine at anorectic doses does not have properties of a dopamine uptake inhibitor.厌食剂量的氟西汀不具备多巴胺摄取抑制剂的特性。
J Neural Transm Gen Sect. 1994;96(3):165-77. doi: 10.1007/BF01294784.
5
Dopamine uptake in platelets: two different low-affinity, saturable mechanisms.血小板中的多巴胺摄取：两种不同的低亲和力、可饱和机制。
Agents Actions. 1981 Jul;11(4):410-6. doi: 10.1007/BF01982479.
6
A study of gamma-aminobutyric acid uptake in normal and Down's syndrome platelets.正常与唐氏综合征血小板中γ-氨基丁酸摄取的研究。
Br J Pharmacol. 1980;71(2):553-6. doi: 10.1111/j.1476-5381.1980.tb10972.x.
7
Platelets and biogenic amines. 1. Platelets are poor investigative models for dopamine re-uptake.血小板与生物胺。1. 血小板并非用于研究多巴胺再摄取的理想模型。
Psychopharmacology (Berl). 1984;84(4):480-5. doi: 10.1007/BF00431453.
8
Biochemical assessment of antidepressive drugs.抗抑郁药物的生化评估。
Br J Clin Pharmacol. 1980 Dec;10(6):539-50. doi: 10.1111/j.1365-2125.1980.tb00508.x.
9
Catecholamines metabolism in infantile autism: a controlled study of 22 autistic children.婴幼儿自闭症中的儿茶酚胺代谢：对22名自闭症儿童的对照研究。
J Autism Dev Disord. 1987 Sep;17(3):333-47. doi: 10.1007/BF01487064.
10
Approaches to the study of cerebral dopamine metabolism in certain extrapyramidal diseases.某些锥体外系疾病中脑多巴胺代谢的研究方法。
Neurosci Behav Physiol. 1985 Mar-Apr;15(2):132-9. doi: 10.1007/BF01186980.
本文引用的文献
1
THE METABOLISM, STORAGE, AND RELEASE OF CATECHOLAMINES.儿茶酚胺的代谢、储存与释放
Recent Prog Horm Res. 1965;21:597-622.
2
5-Hydroxytryptamine deficiency in phenylketonuria.苯丙酮尿症中的5-羟色胺缺乏症。
Lancet. 1957 Mar 16;272(6968):551-3. doi: 10.1016/s0140-6736(57)90920-0.
3
Regional differences in H3-norepinephrine and H3-dopamine uptake into rat brain homogenates.大鼠脑匀浆中H3-去甲肾上腺素和H3-多巴胺摄取的区域差异。
J Pharmacol Exp Ther. 1969 Jan;165(1):78-86.
4
Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.正常受试者以及接受左旋多巴治疗的帕金森病患者血小板对多巴胺的摄取。
Br J Pharmacol. 1970 Aug;39(4):779-88. doi: 10.1111/j.1476-5381.1970.tb09904.x.
5
Uptake, metabolism and release of (3H)-adrenaline by human platelets.人血小板对（3H）-肾上腺素的摄取、代谢及释放
Br J Pharmacol. 1970 Aug;39(4):765-78. doi: 10.1111/j.1476-5381.1970.tb09903.x.
6
Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake.5-羟色胺在大鼠脑切片中的蓄积动力学：与儿茶酚胺摄取的关系。
J Pharmacol Exp Ther. 1970 Nov;175(2):404-18.
7
Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas.大鼠脑匀浆中突触体对儿茶酚胺的摄取：不同脑区的立体特异性
J Pharmacol Exp Ther. 1969 Dec;170(2):221-31.
8
Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.5-羟色胺在血小板中的代谢、转运与储存
Br J Pharmacol Chemother. 1968 Jan;32(1):1-16. doi: 10.1111/j.1476-5381.1968.tb00423.x.
9
Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism.储存池病和白化病中血小板5-羟色胺（血清素）的研究。
J Clin Invest. 1974 Aug;54(2):421-33. doi: 10.1172/JCI107778.
10
Dopamine in the mesolimbic system of the rat brain: endogenous levels and the effects of drugs on the uptake mechanism and stimulation of adenylate cyclase activity.大鼠脑边缘系统中的多巴胺：内源性水平以及药物对摄取机制和腺苷酸环化酶活性刺激的影响。
J Neurochem. 1974 Feb;22(2):265-70. doi: 10.1111/j.1471-4159.1974.tb11589.x.
Zotero 插件