Westbury H A, Parsons G, Allan W H
Aust Vet J. 1984 Jan;61(1):10-3. doi: 10.1111/j.1751-0813.1984.tb07121.x.
The immunogenicity of three Newcastle disease virus (NDV) strains--V4, Hitchner B1 and La Sota, was assessed in chickens that had varying levels of maternal antibody to the virus. Chickens were immunised at different ages by the eye drop and aerosol methods. The immune response of chickens to similar doses of the strains was affected by the presence of maternal antibody. Both the level of maternal antibody and the strain of virus used affected the result. Strain La Sota was least affected as it took higher levels of maternal antibody to depress response to it than were required to have a similar effect on Hitchner B1 and V4. Strain V4 was the strain most affected by circulating maternal antibody. The results demonstrated that strain V4 was less immunogenic than Hitchner B1 and La Sota when used in chickens with maternal antibody to NDV.
在对新城疫病毒（NDV）具有不同水平母源抗体的鸡群中，评估了三种新城疫病毒毒株——V4、希钦纳B1和La Sota的免疫原性。通过滴眼和气雾法在不同日龄的鸡中进行免疫接种。鸡对相似剂量毒株的免疫反应受到母源抗体的影响。母源抗体水平和所使用的病毒毒株均影响结果。La Sota毒株受影响最小，因为与对希钦纳B1和V4产生类似影响相比，需要更高水平的母源抗体才能抑制对它的反应。V4毒株是受循环母源抗体影响最大的毒株。结果表明，当在对新城疫病毒具有母源抗体的鸡中使用时，V4毒株的免疫原性低于希钦纳B1和La Sota毒株。
