Westbury H A, Parsons G, Allan W H
Aust Vet J. 1984 Feb;61(2):47-9. doi: 10.1111/j.1751-0813.1984.tb07190.x.
The clinical response of 7-day-old chickens to Newcastle disease vaccine strains V4, B1 and La Sota administered by the aerosol method was used to study the residual virulence of the strains. Parameters used to assess the severity of the clinical response were the number of sneezes recorded and the weight gain of chickens in the 10 day test period. The demeanour of the chickens was also observed. Strain V4 was less pathogenic for chickens than strain B1 which was less virulent than strain La Sota. Statistically significant differences were recorded in weight gain and the number of sneezes detected in each group. An unexpected mild respiratory disease recorded in chickens dosed with strain V4 may have been associated with administration of virus as a fine particle aerosol.
通过气溶胶法给7日龄雏鸡接种新城疫疫苗株V4、B1和La Sota，观察其临床反应，以研究这些毒株的残余毒力。评估临床反应严重程度的参数包括记录的喷嚏次数以及10天试验期内雏鸡的体重增加情况。同时还观察了雏鸡的行为表现。毒株V4对雏鸡的致病性低于毒株B1，而毒株B1的毒力又低于毒株La Sota。各组雏鸡的体重增加量和检测到的喷嚏次数存在统计学上的显著差异。接种毒株V4的雏鸡出现的意外轻度呼吸道疾病可能与以细颗粒气溶胶形式接种病毒有关。
