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缺氧对记忆巩固的影响:对记忆多阶段模型的启示

Effects of hypoxia on memory consolidation: implications for a multistage model of memory.

作者信息

Allweis C, Gibbs M E, Ng K T, Hodge R J

出版信息

Behav Brain Res. 1984 Feb;11(2):117-21. doi: 10.1016/0166-4328(84)90134-7.

DOI:10.1016/0166-4328(84)90134-7
PMID:6704232
Abstract

Anoxia treatment given 2.5 or 5 min after a single trial passive avoidance task in day-old chicks yielded a temporary retention loss between 20 and 50 min after learning. No effect was obtained when the treatment was administered immediately or 10 min after learning. The temporary retention deficit was not due to a generalized retrieval loss since anoxia given at various times after 10 min following learning with retention tested 30 or 60 min after anoxia treatment, did not yield a retention deficit. Similar findings were obtained with hypoxia. The implications of the results for a multistage model of memory were examined. In particular, it was suggested that the temporary retention deficit may be due to the breakdown of retrieval mechanisms associated with the second stage in a 3-stage model of memory processing.

摘要

对一日龄雏鸡进行单次被动回避任务后2.5分钟或5分钟给予缺氧处理,会在学习后20至50分钟产生暂时的记忆保持缺失。在学习后立即或10分钟给予该处理则没有效果。这种暂时的记忆保持缺陷并非由于一般性的提取缺失,因为在学习后10分钟后的不同时间给予缺氧处理,并在缺氧处理后30或60分钟测试记忆保持情况,并未产生记忆保持缺陷。缺氧处理也得到了类似的结果。研究了这些结果对记忆多阶段模型的影响。特别是,有人提出,这种暂时的记忆保持缺陷可能是由于在记忆处理的三阶段模型中与第二阶段相关的提取机制崩溃所致。

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