Beatty P C, Kay B, Healy T E
Br J Anaesth. 1984 Mar;56(3):223-32. doi: 10.1093/bja/56.3.223.
Using a completely closed anaesthetic circuit, nitrous oxide uptake and nitrogen excretion were measured simultaneously in patients undergoing nitrous oxide in oxygen anaesthesia for abdominal surgery. The results have been compared with standard models of uptake and excretion. Mean nitrous oxide uptake was measured and did not exceed 400 ml min-1 (normalized to 70-kg man) and was not less than 60 ml min-1 at 100 min after the start of nitrous oxide in oxygen anaesthesia. Nitrogen excretion did not exceed 100 ml min-1 and was measurable (8 ml min-1) at 100 min. The persistence of nitrogen excretion contrasts with other published data obtained with intact volunteers and this suggests that exposure at surgery of abdominal tissues, including fat, affects substantially the rates of excretion and uptake after 70 min.
使用完全封闭的麻醉回路，对接受腹部手术的氧化亚氮-氧气麻醉患者同时测量氧化亚氮摄取量和氮排泄量。将结果与摄取和排泄的标准模型进行了比较。测量了氧化亚氮平均摄取量，其不超过400毫升/分钟（按70千克体重的人进行标准化），且在氧化亚氮-氧气麻醉开始后100分钟时不低于60毫升/分钟。氮排泄量不超过100毫升/分钟，在100分钟时可测量（8毫升/分钟）。氮排泄的持续存在与完整志愿者获得的其他已发表数据形成对比，这表明包括脂肪在内的腹部组织在手术中的暴露在70分钟后会显著影响排泄和摄取速率。
