Thomas P R, Lee J Y, Fineberg B B, Razek A A, Perez C A, Land V J, Vietti T J
Cancer. 1984 May 15;53(10):2079-82. doi: 10.1002/1097-0142(19840515)53:10<2079::aid-cncr2820531013>3.0.co;2-e.
Between 1949 and 1978, 119 children with the diagnosis of neuroblastoma or ganglioneuroblastoma were treated at the Washington University Medical Center. Of these, 50 (41%) were alive and disease-free 3 or more years after diagnosis. Important prognostic variables included stage of tumor (Evans staging), histology, age at diagnosis, and site of primary tumor. A stepwise logistic regression analysis of these data has shown that, in order of significance, stage, histology and age at diagnosis are independent prognostic variables. Sex of the patient and nodal status at diagnosis (where known) were not significant prognostic variables. No effects of individual treatment modalities could be detected. This study confirms the overwhelming influence of factors unrelated to treatment in determining the prognosis of neuroblastoma.
1949年至1978年间，华盛顿大学医学中心对119名诊断为神经母细胞瘤或神经节神经母细胞瘤的儿童进行了治疗。其中，50名（41%）在诊断后3年或更长时间存活且无疾病。重要的预后变量包括肿瘤分期（埃文斯分期）、组织学、诊断时的年龄以及原发肿瘤部位。对这些数据进行的逐步逻辑回归分析表明，按重要性排序，分期、组织学和诊断时的年龄是独立的预后变量。患者的性别以及诊断时的淋巴结状态（已知时）不是显著的预后变量。未检测到个体治疗方式的影响。本研究证实了与治疗无关的因素在决定神经母细胞瘤预后方面的压倒性影响。
