Cosgriff T M, Olin D B, Nash D A
J Chronic Dis. 1978 Mar;31(3):195-200. doi: 10.1016/0021-9681(78)90034-6.
A case is reported of hyporeninemic hypoaldosteronism, diagnosed during an evaluation of hyperkalemia. Urine and plasma aldosterone concentrations were depressed despite hyperkalemia and were not responsive to ACTH, cosyntropin, and angiotensin 2. Adrenal glucocorticoid function was normal. Plasma renin activity also was low, and was hyporesponsive to stimulation, including intravascular volume contraction and potassium depletion. Autonomic nervous function was intact. Of the 32 previously reported cases of selective hypoaldosteronism, plasma renin activity was low in the majority of cases in which it was measured. A classification of the types of selective hypoaldosteronism is presented. It is of interest that the serum erythropoietin activity in this case was increased while plasma renin activity was markedly depressed.
报告了1例低肾素性低醛固酮血症病例，该病例在高钾血症评估过程中被诊断出来。尽管存在高钾血症，但尿液和血浆醛固酮浓度仍降低，且对促肾上腺皮质激素、合成促肾上腺皮质激素和血管紧张素2无反应。肾上腺糖皮质激素功能正常。血浆肾素活性也较低，且对包括血管内容量收缩和钾缺乏在内的刺激反应低下。自主神经功能完好。在先前报告的32例选择性低醛固酮血症病例中，多数病例在检测时血浆肾素活性较低。本文提出了选择性低醛固酮血症类型的分类。有趣的是，该病例中血清促红细胞生成素活性增加，而血浆肾素活性明显降低。
