Bronson R A, Cooper G W, Rosenfeld D L
Fertil Steril. 1984 Apr;41(4):609-14. doi: 10.1016/s0015-0282(16)47786-1.
In couples with abnormal postcoital tests, where husbands exhibited autoimmunity to spermatozoa, the degree of impairment of sperm penetration into cervical mucus correlated with the proportion of sperm in ejaculates exhibiting surface-bound immunoglobulins. Residual sperm-directed antibodies detected within seminal fluid were not representative of the cell-bound immunoglobulins present on the sperm surfaces. When all sperm were antibody-bound, spermatozoa were rarely seen in cervical mucus. Conversely, the number of motile sperm seen at postcoital testing was normal, that is, no different from that of antibody-negative couples, when less than 50% of sperm were antibody-bound in the ejaculate. In this group, other causes of infertility should be explored. The extent of autoimmunity to spermatozoa as reflected in the proportion of sperm exhibiting immunobead binding, then, provides guidelines for treatment of these men.
在性交后试验异常的夫妇中，若丈夫表现出对精子的自身免疫，精子穿透宫颈黏液的受损程度与射精中表面结合免疫球蛋白的精子比例相关。精液中检测到的残留精子导向抗体并不代表精子表面存在的细胞结合免疫球蛋白。当所有精子都与抗体结合时，在宫颈黏液中很少见到精子。相反，当射精中不到50%的精子与抗体结合时，性交后试验中见到的活动精子数量正常，即与抗体阴性的夫妇没有差异。在这组人群中，应探索其他不孕原因。那么，精子表现出免疫珠结合的比例所反映的对精子自身免疫的程度，为这些男性的治疗提供了指导。
