Lim H T, Meinders A E, de Haan L D, Bronkhorst F B
Eur J Obstet Gynecol Reprod Biol. 1984 Jan;16(5):327-37. doi: 10.1016/0028-2243(84)90161-8.
The clinical syndrome of the resistant ovary is described in a 24-yr-old woman (XX genotype) with secondary amenorrhea and primary infertility. She presented an increased secretion of gonadotrophins with a decreased secretion of estrogens. In the ovarian tissue only primary ovarian follicles and a thickened tunica albuginea were found. The elevated serum gonadotrophins could be further increased by the administration of exogenous LHRH and incompletely suppressed by exogenous estrogens (50 micrograms ethynylestradiol daily). However, serum LH concentration started with a further rise (positive feedback?) during this estrogen administration. Results of treatment with Cyclocur and ethynylestradiol (100 micrograms daily) in higher dosages are presented. Following discontinuation of the estradiol therapy regular menses resumed, which became ovulatory. The patient became pregnant 23 months after stopping the estradiol therapy.
本文描述了一名24岁女性（XX基因型）的抗卵巢综合征，该患者继发闭经且原发性不孕。她表现为促性腺激素分泌增加而雌激素分泌减少。在卵巢组织中，仅发现了初级卵巢卵泡和增厚的白膜。外源性促性腺激素释放激素（LHRH）给药可使血清促性腺激素进一步升高，外源性雌激素（每日50微克乙炔雌二醇）不能完全抑制其分泌。然而，在给予雌激素期间，血清促黄体生成素（LH）浓度开始进一步升高（正反馈？）。文中还给出了使用更高剂量的环库溴铵和乙炔雌二醇（每日100微克）治疗的结果。停用雌二醇治疗后，月经恢复正常且有排卵。停用雌二醇治疗23个月后，该患者怀孕。
