Watanabe M, Nikaido O, Sugahara T
Int J Cancer. 1984 Apr 15;33(4):483-9. doi: 10.1002/ijc.2910330411.
Studies were done to determine whether hyperthermia alone, or in simultaneous combination with X-rays, can induce malignant transformation in golden hamster embryo cells. Hyperthermia alone did not induce transformation. In fact, it reduced the frequency of the malignant transformation induced by X-rays. DNA damage as measured by alkaline elution and protein degradation were both induced by hyperthermia. However, the relationship of such damage to cell death is not yet clear. Our data indicate that hyperthermia either alone or in combination with X-ray treatment should be a safe method of cancer therapy.
开展了多项研究以确定单纯热疗，或热疗与X射线同时联合使用，是否能诱导金黄地鼠胚胎细胞发生恶性转化。单纯热疗并未诱导转化。事实上，它降低了X射线诱导的恶性转化频率。通过碱性洗脱法测定的DNA损伤和蛋白质降解均由热疗诱导。然而，这种损伤与细胞死亡之间的关系尚不清楚。我们的数据表明，单纯热疗或热疗与X射线治疗联合使用应该是一种安全的癌症治疗方法。
